Mouse sciatic nerve regeneration through semipermeable tubes: A quantitative model
Identifieur interne : 00ED05 ( Main/Exploration ); précédent : 00ED04; suivant : 00ED06Mouse sciatic nerve regeneration through semipermeable tubes: A quantitative model
Auteurs : B. G. Uzman [États-Unis] ; G. M. Villegas [Venezuela]Source :
- Journal of Neuroscience Research [ 0360-4012 ] ; 1983.
English descriptors
- Teeft :
- Abstr periph nerve study group, Avulsed, Axisc, Axisc units, Axon, Axonal elongation, Basal lamina, Blood cells, Cell units, Central zone, Collagen fibers, Connective, Connective regenerated, Connectives regenerated, Distal sciatic stump, Distal stump, Distal stump avulsed, Distal stumps, Double tube, Double tube paradigm, Double tubes, Electron microscopy, Epineurial, Epineurial layers, Fascicle, Fibrocytic, Fibrocytic elements, Fractional area, Functional return, Inner tube, Intercellular matrix, Internal diameter, Internal diameter tubes, Lundborg, Major tissue components, Matrix, Midtube level, Mouse sciatic nerve, Mouse sciatic nerve regenerated, Mouse sciatic nerve regeneration, Myelinated, Myelinated axon, Myelinated fibers, Nerve, Nerve fibers, Nerve regeneration, Nerve stumps, Neural outgrowth, Percent area, Perineurial, Perineurial cells, Perineurium, Peripheral nerve, Peripheral nerve regeneration, Peripheral nerve repair, Present experiments, Proximal, Regenerated, Regenerated connectives, Regeneration, Schwann, Schwann cell units, Schwann cells, Sciatic, Sciatic nerve, Segments regenerated, Semipermeable, Semipermeable tube, Semipermeable tubes, Significant differences, Single tube, Single tubes, Small fascicles, Somatic nerves, Sterile saline, Stump, Tissue component, Tissue components, Tissue cultures, Total area, Total areas, Transected mouse sciatic nerve stumps, Transverse section, Unmy, Unmy axisc units, Unmy units, Unmyelinated, Unmyelinated fibers, Uzman, Villegas.
Abstract
The regeneration of transected mouse sciatic nerves using semipermeable acrylic copolymer tubes to enclose both stumps has been qualitatively assessed from 1 to 30 weeks post‐operative. Quantitative morphometric analysis of electron micrograph montages of complete transverse sections of the segment regenerated between stumps has permitted determinations of the percents of total area occupied by the various tissue constituents—blood vessels, epineurium, perineurium, endoneurium, myelinate d axon/Schwann cell units, and unmyelinated axon/Schwann cell units. Significant differences were found in the total cross‐sectional area of segments regenerated through tubes of 1.0 mm versus 0.5 mm internal diameters. Segments regenerated with the distal stump inserted in the tube contained significantly greater percentages of neural units and were significantly larger at 8 weeks post‐operative compared to segments regenerated for 9‐10 weeks with the distal stump avulsed. The morphometric method permits rapid quantitation of sizeable electron micrograph montages which at 1300 × permit all types of tissue components, including the unmyelinated axons, to be visualized.
Url:
DOI: 10.1002/jnr.490090309
Affiliations:
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Villegas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7B194908B766C0436DBA20E6D97D863F200A83AD</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1002/jnr.490090309</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-NLT464FP-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001C60</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C60</idno><idno type="wicri:Area/Istex/Curation">001C39</idno><idno type="wicri:Area/Istex/Checkpoint">003824</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">003824</idno><idno type="wicri:doubleKey">0360-4012:1983:Uzman B:mouse:sciatic:nerve</idno><idno type="wicri:Area/Main/Merge">00F595</idno><idno type="wicri:Area/Main/Curation">00ED05</idno><idno type="wicri:Area/Main/Exploration">00ED05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mouse sciatic nerve regeneration through semipermeable tubes: A quantitative model</title><author><name sortKey="Uzman, B G" sort="Uzman, B G" uniqKey="Uzman B" first="B. G." last="Uzman">B. G. Uzman</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Correspondence address: V.A. Medical Center, 1030 Jefferson Avenue, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Villegas, G M" sort="Villegas, G M" uniqKey="Villegas G" first="G. M." last="Villegas">G. M. Villegas</name><affiliation wicri:level="1"><country xml:lang="fr">Venezuela</country><wicri:regionArea>Instituto Venezolano de Investigaciones Cientificas, Caracas</wicri:regionArea><wicri:noRegion>Caracas</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Neuroscience Research</title><title level="j" type="alt">JOURNAL OF NEUROSCIENCE RESEARCH</title><idno type="ISSN">0360-4012</idno><idno type="eISSN">1097-4547</idno><imprint><biblScope unit="vol">9</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="338">338</biblScope><biblScope unit="page-count">14</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1983">1983</date></imprint><idno type="ISSN">0360-4012</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-4012</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abstr periph nerve study group</term><term>Avulsed</term><term>Axisc</term><term>Axisc units</term><term>Axon</term><term>Axonal elongation</term><term>Basal lamina</term><term>Blood cells</term><term>Cell units</term><term>Central zone</term><term>Collagen fibers</term><term>Connective</term><term>Connective regenerated</term><term>Connectives regenerated</term><term>Distal sciatic stump</term><term>Distal stump</term><term>Distal stump avulsed</term><term>Distal stumps</term><term>Double tube</term><term>Double tube paradigm</term><term>Double tubes</term><term>Electron microscopy</term><term>Epineurial</term><term>Epineurial layers</term><term>Fascicle</term><term>Fibrocytic</term><term>Fibrocytic elements</term><term>Fractional area</term><term>Functional return</term><term>Inner tube</term><term>Intercellular matrix</term><term>Internal diameter</term><term>Internal diameter tubes</term><term>Lundborg</term><term>Major tissue components</term><term>Matrix</term><term>Midtube level</term><term>Mouse sciatic nerve</term><term>Mouse sciatic nerve regenerated</term><term>Mouse sciatic nerve regeneration</term><term>Myelinated</term><term>Myelinated axon</term><term>Myelinated fibers</term><term>Nerve</term><term>Nerve fibers</term><term>Nerve regeneration</term><term>Nerve stumps</term><term>Neural outgrowth</term><term>Percent area</term><term>Perineurial</term><term>Perineurial cells</term><term>Perineurium</term><term>Peripheral nerve</term><term>Peripheral nerve regeneration</term><term>Peripheral nerve repair</term><term>Present experiments</term><term>Proximal</term><term>Regenerated</term><term>Regenerated connectives</term><term>Regeneration</term><term>Schwann</term><term>Schwann cell units</term><term>Schwann cells</term><term>Sciatic</term><term>Sciatic nerve</term><term>Segments regenerated</term><term>Semipermeable</term><term>Semipermeable tube</term><term>Semipermeable tubes</term><term>Significant differences</term><term>Single tube</term><term>Single tubes</term><term>Small fascicles</term><term>Somatic nerves</term><term>Sterile saline</term><term>Stump</term><term>Tissue component</term><term>Tissue components</term><term>Tissue cultures</term><term>Total area</term><term>Total areas</term><term>Transected mouse sciatic nerve stumps</term><term>Transverse section</term><term>Unmy</term><term>Unmy axisc units</term><term>Unmy units</term><term>Unmyelinated</term><term>Unmyelinated fibers</term><term>Uzman</term><term>Villegas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The regeneration of transected mouse sciatic nerves using semipermeable acrylic copolymer tubes to enclose both stumps has been qualitatively assessed from 1 to 30 weeks post‐operative. Quantitative morphometric analysis of electron micrograph montages of complete transverse sections of the segment regenerated between stumps has permitted determinations of the percents of total area occupied by the various tissue constituents—blood vessels, epineurium, perineurium, endoneurium, myelinate d axon/Schwann cell units, and unmyelinated axon/Schwann cell units. Significant differences were found in the total cross‐sectional area of segments regenerated through tubes of 1.0 mm versus 0.5 mm internal diameters. Segments regenerated with the distal stump inserted in the tube contained significantly greater percentages of neural units and were significantly larger at 8 weeks post‐operative compared to segments regenerated for 9‐10 weeks with the distal stump avulsed. The morphometric method permits rapid quantitation of sizeable electron micrograph montages which at 1300 × permit all types of tissue components, including the unmyelinated axons, to be visualized.</div></front></TEI><affiliations><list><country><li>Venezuela</li><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Uzman, B G" sort="Uzman, B G" uniqKey="Uzman B" first="B. G." last="Uzman">B. G. Uzman</name></region></country><country name="Venezuela"><noRegion><name sortKey="Villegas, G M" sort="Villegas, G M" uniqKey="Villegas G" first="G. M." last="Villegas">G. M. Villegas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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